Thursday, May 16, 2013

Research identifies infection and sepsis-related mortality hotspots across the US

Research identifies infection and sepsis-related mortality hotspots across the US [ Back to EurekAlert! ] Public release date: 15-May-2013
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Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine

First map of its kind reveals key areas for additional research and support services

ATLANTA - In the past, researchers have sought to determine the geographic distribution of many life-threatening conditions, including stroke and cardiac arrest. Now, researchers at the Perelman School of Medicine at the University of Pennsylvania have created the first U.S. map that pinpoints hotspots for infection and severe sepsis related-deaths with notable clusters located in the Midwest, mid-Atlantic, and the South. The research is a critical first step in helping to determine which areas of the country require vital public health resources to fight these deadly diseases. The new research will be presented at the annual meeting of Society for Academic Emergency Medicine in Atlanta, Ga.

"Infection-related deaths are a leading cause of morbidity and mortality in the U.S., affecting over 1 million people a year, and costing $17 billion annually," said lead study author David Gaieski, MD, an associate professor of Emergency Medicine at Penn. "And while our understanding of the causes of infection-related death rates has improved, we are still struggling to prevent these diseases and indentify individuals who are most susceptible. We need to be able to pinpoint the geographic distribution of infection-related death rates in order to further study how and why these infections are happening in these areas and the best methods to prevent these deaths."

Sepsis is the tenth leading cause of death in the United States. With an estimated 750,000 cases annually and a nearly 40 percent mortality rate, severe sepsis is also one of the most common causes of death in hospital critical care units.

To better understand what areas of the country are most at risk for severe sepsis and other infection-related deaths, the research team collected U.S. county death data from the 2010 Multiple Cause of Death data files (compiled by the National Center for Health Statistics) and combined it with 2010 Area Resource File demographic data for a comprehensive view of national variations. The authors note that previous research had only been able to identify potential trends on a state level.

Infection-related deaths were identified using ICD-10 primary cause of death codes for infection and severe sepsis. "Hotspots" were defined as regions where the infection death rate was significantly higher than the national mean and surrounding counties. The analysis revealed four hotspots: 1) two regions that had three times the national mean of infection-related deaths located across the Midwest and mid-Atlantic and 2) two regions that had four times the national death rate from severe sepsis, located in the South and mid-Atlantic.

In addition to the hotspots, the research team also indentified one "coolspot" cluster, an area that had disproportionately low rates of deaths caused by these infections. The coolspot cluster consisted of 157 counties located across the Southwest and Mountain states. The research team notes that these "coolspot" counties might yield important insights as well, including particular screening and treatment protocols that may be in place in these areas.

"This analysis may help target focused geographical interventions to improve the dissemination and implementation of evidence-based care," said senior study author Brendan G. Carr, MD, MA, assistant professor of Emergency Medicine, Surgery, & Epidemiology at Penn. "Further study is required to clarify the geographic variability we observed, but we believe this new resource will be a helpful tool for researchers and public health officials."

###

Additional authors from Penn include Anish Agarwal, MD, MPH, Catherine S. Wolff, Douglas Wiebe, PhD, and Mark E. Mikkelsen, MD.

*map graphic available upon request

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region. Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.

Oral Presentation # 96 - Defining the Geography of Infection-Related Death Rates in the United States: Hotspotting Areas for Targeted Interventions


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Research identifies infection and sepsis-related mortality hotspots across the US [ Back to EurekAlert! ] Public release date: 15-May-2013
[ | E-mail | Share Share ]

Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine

First map of its kind reveals key areas for additional research and support services

ATLANTA - In the past, researchers have sought to determine the geographic distribution of many life-threatening conditions, including stroke and cardiac arrest. Now, researchers at the Perelman School of Medicine at the University of Pennsylvania have created the first U.S. map that pinpoints hotspots for infection and severe sepsis related-deaths with notable clusters located in the Midwest, mid-Atlantic, and the South. The research is a critical first step in helping to determine which areas of the country require vital public health resources to fight these deadly diseases. The new research will be presented at the annual meeting of Society for Academic Emergency Medicine in Atlanta, Ga.

"Infection-related deaths are a leading cause of morbidity and mortality in the U.S., affecting over 1 million people a year, and costing $17 billion annually," said lead study author David Gaieski, MD, an associate professor of Emergency Medicine at Penn. "And while our understanding of the causes of infection-related death rates has improved, we are still struggling to prevent these diseases and indentify individuals who are most susceptible. We need to be able to pinpoint the geographic distribution of infection-related death rates in order to further study how and why these infections are happening in these areas and the best methods to prevent these deaths."

Sepsis is the tenth leading cause of death in the United States. With an estimated 750,000 cases annually and a nearly 40 percent mortality rate, severe sepsis is also one of the most common causes of death in hospital critical care units.

To better understand what areas of the country are most at risk for severe sepsis and other infection-related deaths, the research team collected U.S. county death data from the 2010 Multiple Cause of Death data files (compiled by the National Center for Health Statistics) and combined it with 2010 Area Resource File demographic data for a comprehensive view of national variations. The authors note that previous research had only been able to identify potential trends on a state level.

Infection-related deaths were identified using ICD-10 primary cause of death codes for infection and severe sepsis. "Hotspots" were defined as regions where the infection death rate was significantly higher than the national mean and surrounding counties. The analysis revealed four hotspots: 1) two regions that had three times the national mean of infection-related deaths located across the Midwest and mid-Atlantic and 2) two regions that had four times the national death rate from severe sepsis, located in the South and mid-Atlantic.

In addition to the hotspots, the research team also indentified one "coolspot" cluster, an area that had disproportionately low rates of deaths caused by these infections. The coolspot cluster consisted of 157 counties located across the Southwest and Mountain states. The research team notes that these "coolspot" counties might yield important insights as well, including particular screening and treatment protocols that may be in place in these areas.

"This analysis may help target focused geographical interventions to improve the dissemination and implementation of evidence-based care," said senior study author Brendan G. Carr, MD, MA, assistant professor of Emergency Medicine, Surgery, & Epidemiology at Penn. "Further study is required to clarify the geographic variability we observed, but we believe this new resource will be a helpful tool for researchers and public health officials."

###

Additional authors from Penn include Anish Agarwal, MD, MPH, Catherine S. Wolff, Douglas Wiebe, PhD, and Mark E. Mikkelsen, MD.

*map graphic available upon request

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region. Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.

Oral Presentation # 96 - Defining the Geography of Infection-Related Death Rates in the United States: Hotspotting Areas for Targeted Interventions


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/uops-rii051413.php

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Sunday, May 5, 2013

Police say they didn't release Witherspoon video

AAA??May. 3, 2013?9:06 AM ET
Police say they didn't release Witherspoon video
AP

This image released by ABC news shows co-host George Stephanopoulos, left, interviewing actress Reese Witherspoon on "Good Morning America," Thursday, May 2, 2013 in New York. During the interview, Witherspoon repeatedly apologized for her behavior during an April 19 traffic stop in Georgia. Witherspoon, 37, was arrested after the trooper said she wouldn't stay in the car while her husband, Hollywood agent Jim Toth, was given a field sobriety test. Toth was charged with drunken driving and is due in court May 23. Witherspoon faces a May 22 court hearing on the disorderly conduct charge. (AP Photo/ABC, Ida Mae Astute)

This image released by ABC news shows co-host George Stephanopoulos, left, interviewing actress Reese Witherspoon on "Good Morning America," Thursday, May 2, 2013 in New York. During the interview, Witherspoon repeatedly apologized for her behavior during an April 19 traffic stop in Georgia. Witherspoon, 37, was arrested after the trooper said she wouldn't stay in the car while her husband, Hollywood agent Jim Toth, was given a field sobriety test. Toth was charged with drunken driving and is due in court May 23. Witherspoon faces a May 22 court hearing on the disorderly conduct charge. (AP Photo/ABC, Ida Mae Astute)

This image released by ABC news shows co-host George Stephanopoulos, left, interviewing actress Reese Witherspoon on "Good Morning America," Thursday, May 2, 2013 in New York. During the interview, Witherspoon repeatedly apologized for her behavior during an April 19 traffic stop in Georgia. Witherspoon, 37, was arrested after the trooper said she wouldn't stay in the car while her husband, Hollywood agent Jim Toth, was given a field sobriety test. Toth was charged with drunken driving and is due in court May 23. Witherspoon faces a May 22 court hearing on the disorderly conduct charge. (AP Photo/ABC, Ida Mae Astute)

This image released by ABC news shows co-host George Stephanopoulos, left, interviewing actress Reese Witherspoon on "Good Morning America," Thursday, May 2, 2013 in New York. During the interview, Witherspoon repeatedly apologized for her behavior during an April 19 traffic stop in Georgia. Witherspoon, 37, was arrested after the trooper said she wouldn't stay in the car while her husband, Hollywood agent Jim Toth, was given a field sobriety test. Toth was charged with drunken driving and is due in court May 23. Witherspoon faces a May 22 court hearing on the disorderly conduct charge. (AP Photo/ABC, Ida Mae Astute)

This image released by ABC news shows co-host George Stephanopoulos, left, interviewing actress Reese Witherspoon on "Good Morning America," Thursday, May 2, 2013 in New York. During the interview, Witherspoon repeatedly apologized for her behavior during an April 19 traffic stop in Georgia. Witherspoon, 37, was arrested after the trooper said she wouldn't stay in the car while her husband, Hollywood agent Jim Toth, was given a field sobriety test. Toth was charged with drunken driving and is due in court May 23. Witherspoon faces a May 22 court hearing on the disorderly conduct charge. (AP Photo/ABC, Ida Mae Astute)

FILE - In this April 21, 2013 file photo, Actress Reese Witherspoon attends the premiere of "Mud" hosted by The Cinema Society?with FIJI Water & Levi's at the Museum of Modern Art in New York. Witherspoon recalls that she panicked and said "crazy things" the night she was arrested in Atlanta on a disorderly conduct charge. During an interview on Good Morning America, Thursday, May 2, 2013, Witherspoon repeatedly apologized for her behavior during the April 19 traffic stop. (Photo by Evan Agostini/InvisionAP)

(AP) ? The Georgia State Patrol says it did not release the video from a state trooper's dash-camera showing a combative Reese Witherspoon confronting the officer during a traffic stop in Atlanta.

The video was first obtained by the celebrity website TMZ and rebroadcast by other news media. Witherspoon was arrested on a charge of disorderly conduct.

Georgia State Patrol spokesman Gordy Wright said Friday that the video would be officially released soon. He told The Associated Press no one from his agency leaked the video, and the only copy that had been made earlier was for the prosecutor.

The video shows Witherspoon asking the trooper, "Do you know my name" and then adding, "You're about to find out who I am."

The actress later apologized for her behavior.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-03-Reese%20Witherspoon%20Arrest/id-63c0e7a56030491f8426a4101d7fca1b

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Friday, May 3, 2013

Sex Supplements Recalled Due to Undeclared Drugs

May 1 (Reuters) - Post position for Saturday's 139th Kentucky Derby at Churchill Downs after Wednesday's draw (listed as barrier, HORSE, jockey, trainer) 1. BLACK ONYX, Joe Bravo, Kelly Breen 2. OXBOW, Gary Stevens, D. Wayne Lukas 3. REVOLUTIONARY, Calvin Borel, Todd Pletcher 4. GOLDEN SOUL, Robby Albarado, Dallas Stewart 5. NORMANDY INVASION, Javier Castellano, Chad Brown 6. MYLUTE, Rosie Napravnik, Tom Amoss 7. GIANT FINISH, Jose Espinoza, Tony Dutrow 8. GOLDENCENTS, Kevin Krigger, Doug O'Neill 9. OVERANALYZE, Rafael Bejarano, Todd Pletcher 10. PALACE MALICE, Mike Smith, Todd Pletcher 11. ...

Source: http://news.yahoo.com/sex-supplements-recalled-due-undeclared-drugs-212348360.html

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The Stinky Gaming Footboard Hits Its Kickstarter Goal, Proving PC ...

Innovation FTW! The Stinky Gaming Footboard reached its Kickstarter goal. The novel gaming controller is headed to production.

I have a Stinky under my desk right now. Much to my surprise, the controller earned a place in my life. I reviewed the unit several weeks ago and doubted it was more than a novelty. But it?s still there and I?m starting to really enjoy using it.

The controller gets your foot into the gaming action. It?s a large, four-way controller. It?s not complicated. I have mine set to throw a grenade when I press forward and to crouch when pressing down. There are left and right commands as well if you?re more coordinated than me.

The Montreal, Canada-based company was looking for $75,000 on Kickstarter. They just hit that goal with $79,562 pledged. Over 440 units were pre-ordered.

Kickstarter is the perfect venue for an item like the Stinky. Before online crowdfunding went mainstream in 2012, a startup would have to raise crazy cash to fill a warehouse with their items with the hope they will sell. At best the startup would ink a deal with Best Buy or RadioShack. At worst the founders would drain the life savings of their friends and families.

But no more! Now, thanks to Kickstarter, Indiegogo and the rest of the Internet, startups can hedge their future on a successful video and viral marketing. The future!

IMG_7012

Source: http://techcrunch.com/2013/05/03/the-stinky-gaming-footboard-hits-its-kickstarter-goal-proving-pc-gamers-are-more-coordinated-than-previously-thought/

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NPD: Majority of gamers play online | Games industry news | MCV

A new NPD report has found that the number of players gaming online ? along with the number of hours spent by those players online ? has increased significantly.

NPD Group's Online Gaming 2013 report surveyed over 8,800 US gamers, and found that 72 per cent stated they played games online. That's up from the 67 per cent reported for the year prior.

The report claimed that the average weekly time spent playing online by these respondents was up 6 per cent, while overall gaming time per week was up 9 per cent. The NPD notes the increase in time online was mirrored across ?virtually every type of device,? with PC out in front with 68 per cent (down from 72 per cent last year).

Meanwhile, Mobile showed a significant boost from the year prior, grabbing 56 per cent of the applicable online gaming contingent polled.

The report also found that 62 per cent of players preferred to buy physical games, down from 65 per cent last year.

"While many gamers prefer games in the physical format, the increased availability of digital content paired with a greater amount of connected devices has driven an increase in the number of consumers going online to access the content they want," said NPD analyst Liam Callahan.

Source: http://www.mcvuk.com/news/read/npd-majority-of-gamers-play-online/0115028

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Police, politicians push surveillance post-Boston

File - This Jan. 8, 1997 file photo shows a remote camera for the Los Angeles Department of Transportation oversees the traffic flow on the corner of Wilshire and Veteran in the Westwood area of Los Angeles. In small towns and big cities, police and politicians are pointing to the surveillance video that was key to identifying the Boston Marathon bombing suspects as a reason to bolster their own networks and get more electronic eyes on their streets. In Los Angeles, a councilman wants police to broaden their network by giving them access to traffic cameras used to monitor the flow of cars on the road. (AP Photo/Michael Caulfield,File)

File - This Jan. 8, 1997 file photo shows a remote camera for the Los Angeles Department of Transportation oversees the traffic flow on the corner of Wilshire and Veteran in the Westwood area of Los Angeles. In small towns and big cities, police and politicians are pointing to the surveillance video that was key to identifying the Boston Marathon bombing suspects as a reason to bolster their own networks and get more electronic eyes on their streets. In Los Angeles, a councilman wants police to broaden their network by giving them access to traffic cameras used to monitor the flow of cars on the road. (AP Photo/Michael Caulfield,File)

This Wednesday, April 24,2013 photo shows transportation engineer associate Abeer Kliefe working at the Los Angeles Department of Transportation's Automated Traffic Surveillance and Control Center in downtown Los Angeles. In small towns and big cities, police and politicians are pointing to the surveillance video that was key to identifying the Boston Marathon bombing suspects as a reason to bolster their own networks and get more electronic eyes on their streets. In Los Angeles, a councilman wants police to broaden their network by giving them access to traffic cameras used to monitor the flow of cars on the road. (AP Photo/Reed Saxon)

(AP) ? Police and politicians across the U.S. are pointing to the example of surveillance video that was used to help identify the Boston Marathon bombing suspects as a reason to get more electronic eyes on their streets.

From Los Angeles to Philadelphia, efforts include trying to gain police access to cameras used to monitor traffic, expanding surveillance networks in some major cities and enabling officers to get regular access to security footage at businesses.

Some in law enforcement, however, acknowledge that their plans may face an age-old obstacle: Americans' traditional reluctance to give the government more law enforcement powers out of fear that they will live in a society where there is little privacy.

"Look, we don't want an occupied state. We want to be able to walk the good balance between freedom and security," Los Angeles police Deputy Chief Michael Downing, who heads the department's counter-terrorism and special operations bureau.

"If this helps prevent, deter, but also detect and create clues to who did (a crime), I guess the question is can the American public tolerate that type of security," he said.

The proliferation of cameras ? both on street corners and on millions of smartphones ? have helped catch lawbreakers, but plans to expand surveillance networks could run up against the millions of dollars it can cost to install and run the networks, expert say.

Whatever Americans' attitudes or the costs, experts say, the use of cameras is likely to increase in the coming years, whether they are part of an always-on, government-run network or a disparate, disorganized web of citizens' smartphones and business security systems.

"One of the lessons coming out of Boston is it's not just going to be cameras operated by the city, but it's going to be cameras that are in businesses, cameras that citizens use," said Chuck Wexler, the executive director of the Police Executive Research Forum. "You'll see the use of cameras will skyrocket."

Part of the push among law enforcement agencies is for greater integration of surveillance systems. For decades, law enforcement has contacted businesses for video after a crime. An integrated network would make that easier, advocates say.

Since the Boston bombings, police officials have been making the case for such a network.

In Philadelphia, the police commissioner appealed last week to business owners with cameras in public spaces to register them with the department. In Chicago, the mayor wants to expand the city's already robust network of roughly 22,000 surveillance video.

And in Houston, officials want to add to their 450 cameras through more public and private partnerships. The city already has access to hundreds of additional cameras that monitor the water system, the rail system, freeways and public spaces such as Reliant Stadium, officials said.

"If they have a camera that films an area we're interested in, then why put up a separate camera?" said Dennis Storemski, director of the mayor's office of public safety and homeland security. "And we allow them to use ours too."

In Los Angeles, police have been working on building up a regional video camera system funded by about $10 million in federal grant dollars over the last several years that would allow their network to be shared with nearby cities at the flip of a switch, Downing said.

That effort is in addition to a recent request by an LA councilman who wants the city to examine allowing police access to cameras used to monitor traffic flow. If that happens, the LAPD's network of about 700 cameras would grow to more than 1,000.

"First, it's a deterrent and, second, it's evidence," Downing said, adding, "it helps us in the hunt and pursuit."

Law enforcement experts say police need these augmented systems because the bystander with a smartphone in hand is no substitute for a surveillance camera that is deliberately placed in a heavy crime area.

"The general public is not thinking about the kinds of critical factors in preventing and responding to crimes," said Brenda Bond, a professor who researches organizational effectiveness of police agencies at Suffolk University in Boston. "My being in a location is happenstance, and what's the likelihood of me capturing something on video?"

The U.S. lags behind other countries in building up surveillance. One reason is the more than 18,000 state and local law enforcement agencies that each determines its own policy. Another reason is cost: A single high-definition camera can cost about $2,500 ? not including the installation, maintenance or monitoring costs.

Law enforcement budgets consist of up to 98 percent personnel costs, "so they don't necessarily have the funding for new technologies," Bond said.

There are also questions about their effectiveness. A 2011 Urban Institute study examined surveillance systems in Baltimore, Chicago and Washington, and found that crime decreased in some areas with cameras while it remained unchanged in others. The success or failure often depended on how the system was set up and monitored in each city.

While its deterrent effect remains debated, however, there's general agreement that the cameras can be useful after a crime to help identify suspects.

Cameras, for instance, allowed police in Britain to quickly identify the attackers behind the deadly 2005 suicide bombings in London. The country has more than 4.3 million surveillance cameras, primarily put in place after the IRA terror attacks.

Dozens are said to sit today around the house of George Orwell, the author of "1984," a story that foretold of a "Big Brother" society. Privacy advocates in the U.S. are concerned that the networks proposed by officials today could grow to realize Orwell's dystopic vision.

In recent years, traffic cameras used to catch scofflaw drivers running a red light or speeding have received widespread backlash across the country: An Ohio judge ordered a halt to speed camera citations, Arizona's Department of Public Safety ceased its program, and there have been efforts to ban such cameras in Iowa.

Amie Stepanovich, director of the Electronic Privacy Information Center's Domestic Surveillance Project, said the most concerning was an integrated network of cameras that could allow authorities to track people's movements.

Such a network could allow be upgraded later with more "invasive" features like facial recognition, Stepanovich said, noting that the Boston surveillance footage was from a private security system at a department store that was not linked to law enforcement.

In many cases, the public may not be aware of the capabilities of the technology or what is being adopted by their local police department and its implications, said Peter Bibring, senior staff attorney for the American Civil Liberties Union of Southern California.

Unlike private security systems monitored by businesses or citizens' smartphones, Bibring said, a government-run network is a very different entity because those watching have "the power to investigate, prosecute and jail people."

___

Tami Abdollah can be reached at http://www.twitter.com/latams

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-05-02-Marathon%20Bombings-Electronic%20Eyes/id-fd89bfc7fc9c4de89e1552d229d10324

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Packaged Chrome apps now searchable in dev channels for Chrome OS and Windows

Packaged Chrome apps now available on Dev Channels for Chrome OS and Windows

While Google opened the door to packaged Chrome apps back in February, it's been a largely one-way affair ever since -- developers could upload the native-style apps, but they couldn't find anything without a direct link. As of a dev channel update, the relationship is a little more two-directional. Both Chrome OS and Windows-based Chrome testers can at last search for packaged apps in the Chrome Web Store alongside the usual releases. Google is mostly holding back on wider access to give developers more time to polish their work. Us non-coders will have to be patient, then, but truly offline-friendly apps just came one step closer.

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Via: Chromium Blog

Source: Chromium Projects

Source: http://www.engadget.com/2013/05/02/packaged-chrome-apps-now-discoverable-in-dev-channels/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Top Picks: Henri the cat's philosophical musings, HBO's specials on childhood obesity, and more

A PBS documentary explores the life of ukulele player Jake Shimabukuro, Venmo lets phone users transfer money from one device to another, and more top picks.

By Staff / May 3, 2013

Le chat noir

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Perhaps you have heard of Henri, the YouTube sensation and now Friskies spokescat. He is a beautiful black-and-white tuxedo feline who expresses his existential angst through half-lidded eyes with a touch of parody (?My thumbs are not opposable, yet I oppose everything.?). Now Henri, le Chat Noir appears in book form as black-and-white photos with furry philosophical musings certain to crack a smile from even the most hardened cynic.

A necessary appointment

Call it poetic license: The Waterboys have created an entire album from the poems of W.B. Yeats. An Appointment with Mr. Yeats finds the Celtic rock band returning to the 1980s sound they dubbed ?the big music.? Fiddle player Steve Wickham brings a gentle caress to ?Sweet Dancer? and frays his frenzied bow during ?Mad as the Mist and Snow.? Mike Scott has seldom sung as soulfully, especially on ?Song of Wandering Aengus.? It?s The Waterboys? best record since ?Fisherman?s Blues.?

Text me some cash?

Caught cash-less? Venmo lets people transfer money from one smart phone to another. Pay your friends for those concert tickets or give your share of the rent with just a few taps. Each payment comes with a personalized note, making exchanges clear, social, and fun. Credit-card transactions carry a 3 percent fee but everything else is free, and Venmo is FDIC approved. It?s available for iPhone, Android, and BlackBerry.

Native son

Byron Janis, one of America?s first acclaimed native-born pianists, began his career studying in New York with the legendary Josef and Rosina Lh?vinne. RCA Red Seal celebrates his 85th birthday (April 16) with a box set of his entire discography newly remastered from original sources, Byron Janis: The Complete RCA Collection. Selections include Beethoven sonatas (Tempest, Waldstein), Mussorgsky?s ?Pictures at an Exhibition,? Rachmaninoff?s Piano Concerto No. 1, and many others by Bach, Liszt, Chopin, and Gershwin. The 11-CD-set also includes a DVD documentary, ?The Byron Janis Story,? produced by Peter Rosen.

Ukeman

Life on Four Strings, a PBS documentary about ?accidental superstar? and ?ukulele hero? Jake Shimabukuro, airs May 10. The film visits his early years in Hawaii, his breakout viral YouTube video of ?While My Guitar Gently Weeps,? and his international success topping the Billboard charts. If you have ever doubted the lowly uke could be a first-class musical instrument, tune in and doubt no more.

Weighty subject

HBO tackles childhood obesity and the responsibility of parents in The Weight of the Nation for Kids on May 7. This three-part series of half-hour specials follows the ?Weight of the Nation? documentaries that aired in May 2012. This round is especially designed to help young people and their families make food and activity choices that will improve their health now and in the future.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/2BVgu-ce08I/Top-Picks-Henri-the-cat-s-philosophical-musings-HBO-s-specials-on-childhood-obesity-and-more

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Turkmen leader's horse fall hidden from nation

MOSCOW (AP) ? Seeing the president slam face-first into the ground after falling from a speeding horse would be a shock to any nation. In authoritarian Turkmenistan, many residents didn't even get the chance.

President Gurbanguli Berdymukhamedov apparently wasn't seriously injured Sunday when his horse stumbled and he pitched into the dirt track at the hippodrome on the outskirts of the capital, Ashgabat. But the fall was certainly a wound to the pride of the 55-year-old Central Asian leader, whose all-powerful personality cult portrays him as effortlessly competent.

Thousands of people were in the stands for the race that celebrated Turkmenistan's renowned desert racehorse breed, the Akhal-Teke. But state television's video of the race cut off just before the fall and the extensive written reports on the event didn't mention the plunge.

All domestic broadcasting in Turkmenistan is state-run; newspapers are either state-run or under heavy government supervision. Media criticism of the president is non-existent and elaborate praise of him is ubiquitous in this nation of 5 million, wedged between the Caspian Sea and Iran, Afghanistan and Uzbekistan.

Turkmenistan's security agencies reportedly went into high gear to try to block video or images of the president's fall from slipping out to the rest of the world. The opposition-in-exile group Gundogar cited witnesses as saying police were carefully checking the computers, tablets, mobile phones and cameras of departing passengers at Ashgabat's airport. The horse celebration had attracted an array of foreign horse enthusiasts.

Video obtained by The Associated Press shows a rider falling when his horse stumbles just after crossing the finish line in first place. State media reported that Berdymukhamedov won the race.

The horse also fell, but quickly got up, showing a slight limp. Berdymukhamedov, however, lay motionless. Within seconds, several dozen men in dark suits and one in traditional garb including a high white sheepskin hat rushed onto the track, and an ambulance soon arrived.

The man who shot the video spoke on condition of anonymity for fear that divulging his name could have negative repercussions on his livelihood. He said the president reappeared about half an hour later to accept the winner's prize ? about $11 million.

State TV showed the president accepting the award, which he said would be used to improve Turkmenistan's horse breeding.

The choreographed winning of the race ? the nearest challenger was obviously throttling back his mount in the home stretch ? the media censorship and the reported tough security response at the airport all reflect Turkmenistan's two decades of stifling authoritarianism.

Since becoming independent in the 1991 collapse of the Soviet Union, Turkmenistan has been an extreme example of a one-party state.

Its first leader, Saparmurat Niyazov, developed a pervasive personality cult that included renaming months of the year after his family members. He also mandated that all schoolchildren study his rambling spiritual guide and once claimed that reading it three times would guarantee the reader a berth in heaven.

Some of his measures verged on black comedy, including banning opera and ballet because they did not reflect traditional Turkmen culture and banning lip-synching on the grounds that it weakened Turkmens' ability to become skilled singers.

Berdymukhamedov, who became president after Niyazov's death in 2006, has put aside some of Niyazov's more extreme measures, but he has not opened up Turkmenistan's politics or media. His own personality cult includes such feats as winning last year's maiden automobile race in Turkmenistan, even though he supposedly wasn't scheduled to take part and asked to join only at the last minute.

State media reports about the president's actions overflow with admiration and delight.

"The audience greeted President Gurbanguli Berdymukhamedov, who finished first ? demonstrating great skills of horse riding, the will to win, firmness and courage ? with a storm of applause," the state news agency TDH reported after Sunday's race.

Source: http://news.yahoo.com/turkmen-leaders-horse-fall-hidden-nation-140818857.html

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Governors, GOP Allies Clash Over Tax Cuts (WSJ)

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Obama, Mexican president talk economy, security

MEXICO CITY (AP) ? President Barack Obama sought on Thursday to tamp down a potential rift with Mexico over a dramatic shift in the cross-border fight against drug trafficking and organized crime, acceding that Mexicans had the right to determine how best to tackle the violence that has plagued their country.

Since taking office in December, Mexican President Enrique Pena Nieto has moved to end the widespread access that U.S. security agencies have had in Mexico to tackle the violence that affects both sides of the border. It's a departure from the strategy employed by his predecessor, Felipe Calderon, which was praised by the U.S. but reviled by many Mexicans.

Obama said the shifting security relationship would not hurt cooperation between the neighboring nations.

"I agreed to continue our close cooperation on security, even as the nature of that cooperation will evolve," Obama said during a joint news conference at Mexico's grand National Palace. "It is obviously up to the Mexican people to determine their security structures and how it engages with the other nations ? including the United States."

Pena Nieto as well downplayed the notion that the new, more centralized arrangement would damage its security partnership with the United States. He said Obama agreed during their private meeting earlier in the day to "cooperate on the basis of mutual respect" to promote an efficient and effective strategy.

Obama arrived in Mexico Thursday afternoon for a three-day trip that will also include a stop in Costa Rica. Domestic issues followed the president south of the border, with Obama facing questions in his exchange with reporters about the potential escalation of the U.S. role in Syria, a controversy over contraception access for teenage girls, and the delicate debate on Capitol Hill on an immigration overhaul.

The latter issue is being closely watched in Mexico, given the large number of Mexicans who have emigrated to the U.S. both legally and illegally. More than half of the 11 million people in the U.S. illegally are Mexican, according to the Pew Research Center.

For Obama, the immigration debate is rife with potential political pitfalls. While he views an overhaul of the nation's patchwork immigration laws as a legacy-building issue, he's been forced to keep a low-profile role in the debate to avoid scaring off wary Republicans.

In an effort to court those GOP lawmakers, the draft bill being debated on Capitol Hill focuses heavily on securing the border with Mexico, and makes doing so a pre-condition for a pathway to citizenship for those in the U.S. illegally. But Florida Republican Sen. Marco Rubio, one of the bill's architects, said Thursday that unless the border security measures are made even tougher, the legislation will face tough odds not only in the GOP-controlled House but also in the Democratic-led Senate.

The president acknowledged there were some areas along the 2,000-mile border between the U.S. and Mexico where security needs to be tightened. But he gently chided Rubio and other Republicans for putting up obstacles that would derail final legislation.

"I suspect that the final legislation will not contain everything I want. It won't contain everything that Republican leaders want, either," Obama said. He added that "what I'm not going to do is to go along with something where we're looking for an excuse not to do it as opposed to a way to do it."

Despite the intense interest in the immigration debate among Mexicans, Pena Nieto carefully avoided injecting himself in the issue. While he commended the U.S. for tackling the challenge, he said the congressional debate "is a domestic affair."

The new Mexican leader was purposely seeking to avoid the perceived missteps of former Mexican President Vicente Fox, who irked conservatives in the U.S. by lobbying for an immigration overhaul in 2001.

Pena Nieto's election brought Mexico's Institutional Revolutionary Party, or PRI, back to power after a decade on the sidelines. The security changes are emblematic of the party's preference for centralized political and bureaucratic control.

The arrangement means all contact for U.S. law enforcement will now go through a "single door," according to Mexico's federal Interior Ministry, the agency that controls security and domestic policy. Under the previous policy, FBI, CIA, DEA and border patrol agents had direct access to units of Mexico's Federal Police, army and navy. U.S. agents worked side by side with those Mexican units in the fight against drug cartels, including the U.S.-backed strategy of killing or arresting top kingpins.

Obama lauded his Mexican counterpart for launching bold reforms during his first months in office, not only on security but also the economy. Both leaders have said they want to refocus the U.S.-Mexico relationship on trade and the economy, not the drug wars and immigration issues that have dominated the partnership in recent years.

In a nod to that effort, Obama and Pena Nieto announced a new partnership for closer cooperation between top officials in both countries. Vice President Joe Biden will also participate in that process, Obama said.

Already the economic relationship between the two countries is robust, with Mexico accounting for $500 billion in U.S. trade in 2011 and ranking as the second-largest export market for U.S. goods. A stronger Mexican economy would result in even more trade and job growth on both sides of the border, Obama aides say.

On Friday, Obama will speak to an audience of Mexican students before heading to Costa Rica for talks with Central American leaders. His meetings there are expected to focus on bolstering regional economic cooperation, as well as security issues.

___

Follow Julie Pace at http://twitter.com/jpaceDC

Source: http://news.yahoo.com/obama-mexican-president-talk-economy-security-222300325.html

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Thursday, May 2, 2013

E-Reading Rainbow: Hachette to bring entire e-book catalog to public libraries

EReading Rainbow Hachette to bring entire ebook catalog to public libraries next week

If you're still balking at the cost of download-to-own e-books, and would rather stick to the tried-and-true library lending system, then this Hachette news is for you. Come next Wednesday, the entirety of Hachette's ebook catalog -- over 5,000 titles -- will be made available to nonprofit libraries throughout the US. The announcement and finalized pricing model follows two years worth of pilot testing, during which the publisher examined ebook consumption and lending habits at select libraries. Under the currently set terms of sale, e-books that bow in tandem with print editions will run three times the price of their physical counterparts for "single-user-at-a-time circulations, " with prices falling to just one and a half that of the hard copy one year later. By Hachette's own admission, this pricing scheme is not entirely set in stone -- the company plans to continually reevaluate the model on a per-year basis. So, there's hope yet the publisher will gouge libraries a bit less for the perks of e-borrowing.

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Source: http://www.engadget.com/2013/05/01/hachette-ebook-catalog-public-libraries/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Membrane remodeling: Where yoga meets cell biology

Wednesday, May 1, 2013

Cells ingest proteins and engulf bacteria by a gymnastic, shape-shifting process called endocytosis. Researchers at the National Institutes of Health revealed how a key protein, dynamin, drives the action.

Endocytosis lets cells absorb nutrients, import growth factors, prevent infections and accomplish many other vital tasks. Yet, despite decades of research, scientists don't fully understand this membrane remodeling process. New research reveals, on the real-life scale of nanometers, how individual molecules work together during a single act of endocytosis.

"We've discovered new details about a basic process used in all sorts of ways by every cell in the body," said co-author Joshua Zimmerberg, M.D., Ph.D., head of the Program in Physical Biology at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), where the research was conducted. "It's the culmination of a 30-year journey."

The research was led by Vadim Frolov, Ph.D., a former postdoctoral fellow in Dr. Zimmerberg's lab. It appears in a Science paper co-authored by an international team of researchers in the United States, Spain, Russia and India.

In addition to funding Dr. Zimmerberg, NIH also supported the work through a grant from the National Institute of General Medical Sciences (NIGMS) to co-author Sandra Schmid, Ph.D. at the University of Texas Southwestern Medical Center in Dallas. Dr. Schmid is an expert on dynamin.

Scientists have known for years that dynamin plays the major role in endocytosis. After other molecules known as coat proteins pinch the cell's membrane to form an inward-puckering sac, dynamin wraps, python-like, around the neck of the sac and squeezes it tightly. A jolt of energy from a molecule called GTP severs the neck, releasing a free-floating bubble, called a vesicle, inside the cell, and sealing the cell's outer membrane shut. All the while, neither the cell nor the vesicle leak any of their contents.

Drs. Zimmerberg, Schmid and colleagues discovered how the cell overcomes a seemingly insurmountable energy barrier to accomplish this feat. It's not a matter of brute force, as previously suspected, but something much more zen-like?molecular cooperation.

Neck severing starts when dynamin dips slightly into the pliable cell membrane. Lipids (oily molecules) in the membrane move aside, shifting their tails to accommodate the protein. This molecular crowding stresses the membrane, further constricting the neck of the developing vesicle.

Then GTP finishes the job. But not, as you might expect, with a fatal tug of the dynamin noose. Rather the opposite: Like a yoga instructor, GTP encourages the membrane to relax, despite its extreme stress. In the middle of this state of relaxation, the vesicle suddenly pinches off.

In trying to understand this counterintuitive move, the researchers speculate that GTP melts the inside of dynamin a bit, turning the protein into a flexible scaffold that stabilizes the membrane while the lipids rearrange themselves.

"We see no other way to lower the energy barrier to remodeling without having any leaks," states Dr. Frolov, who formulated the idea.

The researchers also found that, without access to GTP, dynamin will keep growing, twisting three or four times around the neck of the sac. When GTP is present (as is the case in living organisms), it only lets dynamin coil once or twice before it snaps off the vesicle.

All of this information helps scientists better understand a process critical to life.

Genetic defects in endocytosis?and the reverse process, exocytosis?are linked to a host of human diseases, including muscular dystrophy, Alzheimer's disease, leukemia and many others. In addition, some parasites and other pathogens can hijack endocytosis, commandeering the process to enter and infect human cells.

Dr. Zimmerberg is bringing his basic research findings to the clinic. He is studying changes in muscle cell membranes in people who have an adult-onset form of muscular dystrophy. In the disease, the membrane around muscle cells weakens and tears. Eventually, cells with damaged membranes die, leaking a number of enzymes into the bloodstream. Dr. Zimmerberg hopes to identify changes in blood chemistry that shed light on the disease process and point to possible new treatments. The study soon will begin recruiting patients as volunteers.

###

NIH/National Institute of General Medical Sciences: http://www.nigms.nih.gov

Thanks to NIH/National Institute of General Medical Sciences for this article.

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Source: http://www.labspaces.net/128056/Membrane_remodeling__Where_yoga_meets_cell_biology

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Calif. may move 3,000 inmates at risk of lung disease

By Sharon Bernstein

LOS ANGELES, May 1, 2013 - As many as 3,000 prison inmates in central California deemed to be at risk from a potentially lethal lung disease may need to be moved to other regions under an order from a court-appointed federal overseer.

The directive, issued on Monday, marks the latest effort to stem cases of valley fever, or coccidioidomycosis, at two prisons where the disease was found to have contributed to the deaths of nearly three dozen inmates from 2006 to 2011.

But it could complicate court-ordered efforts to reduce overcrowding across California's prison system, the nation's largest.

The pneumonia-like illness, contracted by inhaling fungal spores that grow in the dry soils of the American Southwest, is not contagious. But the spores become airborne when soil is disturbed by wind, construction, farming and other activities.

Problems with the disease at two prisons in San Joaquin Valley, the state's agricultural heartland, were documented on Wednesday in court papers filed by J. Clark Kelso, appointed as a federal receiver for medical issues at the California Department of Corrections and Rehabilitation.

Previous attempts to reduce both the number of infections and the severity of cases were ineffective, Kelso's spokeswoman, Joyce Hayhoe, told Reuters.

After a report last year found that problems continued at Pleasant Valley State Prison and Avenal State Prison, Kelso asked correctional officials to stop transferring some inmates there who were considered to be at high risk, Hayhoe said.

Among those deemed to be at higher risk of contracting or dying from the disease were African-Americans, inmates of Filipino heritage, those with compromised immune systems and those who older than 55.

On Monday, Kelso went a step further, directing the state to cease housing inmates who fell into those categories at the two prisons in question, though he stopped short of explicitly ordering those inmates to be transferred out.

On Wednesday, he added diabetics to the list of high-risk inmates, court papers showed. He called the state's response so far "anemic."

'ENORMOUS UNDERTAKING'

Jeffrey Callison, a spokesman for the Corrections Department, acknowledged that the state has not stopped sending at-risk prisoners to the two facilities, nor have any been moved out. Kelso's directive to stop housing vulnerable prisoners in the region came "out of the blue," he said.

Callison said that immediately complying with the receiver's directive "would be an enormous undertaking."

Dr. John Galgiani, a valley fever expert hired by lawyers representing inmates, agreed with the federal receiver and prison officials that no outbreak of the disease had been declared in the San Joaquin Valley.

But in his own court filing, Galgiani said the persistence of the illness in the two prisons amounted to a "medical emergency."

Noting a recent report by Kelso's office, Galgiani said in a court declaration that the infection rate at Pleasant Valley State Prison was "1,000 times the rate for Californians generally." Valley fever was a contributing cause of death in 34 cases between 2006 and 2011 in the two institutions, he wrote.

Symptoms of valley fever include a cough, fever, chest pains and muscle aches that can last for many weeks or months. But fewer than half of infected individuals become sick, and only a small percentage become severely ill.

The disease can be fatal, but the mortality rate among infected patients is about 0.1 percent, said Galgiani, an infectious disease specialist who directs the University of Arizona Valley Fever Center for Excellence.

A recent study found that Valley fever was identified as an underlying or contributing cause to 3,089 U.S. deaths during an 18-year span, from 1990 to 2008.

Those most at risk for life-threatening complications from the illness include the elderly and people with compromised immune systems, Galgiani said.

An estimated 150,000 infections occur in the Southwest each year, the majority of them in Arizona. California accounts for nearly all the remaining cases.

(This story refiles to remove an extraneous word in the first paragraph)

(Additional reporting by Steve Gorman; Editing by Dan Whitcomb and Philip Barbara)

Source: http://news.yahoo.com/california-may-move-3-000-inmates-risk-valley-005340767.html

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Fossil of great ape sheds light on evolution

May 1, 2013 ? Researchers who unearthed the fossil specimen of an ape skeleton in Spain in 2002 assigned it a new genus and species, Pierolapithecus catalaunicus. They estimated that the ape lived about 11.9 million years ago, arguing that it could be the last common ancestor of modern great apes: chimpanzees, orangutans, bonobos, gorillas and humans. Now, a University of Missouri integrative anatomy expert says the shape of the specimen's pelvis indicates that it lived near the beginning of the great ape evolution, after the lesser apes had started to develop separately but before the great ape species began to diversify.

Ashley Hammond, a Life Sciences Fellow in the MU Department of Pathology and Anatomical Sciences, is the first to examine the pelvis fragments of the early hominid. She used a tabletop laser scanner attached to a turntable to capture detailed surface images of the fossil, which provided her with a 3-D model to compare the Pierolapithecus pelvis anatomy to living species.

Hammond says the ilium, the largest bone in the pelvis, of the Pierolapithecus catalaunicus is wider than that of Proconsul nyanzae, a more primitive ape that lived approximately 18 million years ago. The wider pelvis may be related to the ape's greater lateral balance and stability while moving using its forelimbs. However, the fingers of the Pierolapithecus catalaunicus are unlike those of modern great apes, indicating that great apes may have evolved differently than scientists originally hypothesized.

"Pierolapithecus catalaunicus seemed to use a lot of upright behaviors such as vertical climbing, but not the fully suspensory behaviors we see in great apes alive today," Hammond said. "Today, chimpanzees, orangutans, bonobos and gorillas use forelimb-dominated behaviors to swing below branches, but Pierolapithecus catalaunicus didn't have the long, curved finger bones needed for suspension, so those behaviors evolved more recently."

Hammond suggests researchers continue searching for fossils to further explain the evolution of the great apes in Africa.

"Contrary to popular belief, we're not looking for a missing link," Hammond said. "We have different pieces of the evolutionary puzzle and big gaps between points in time and fossil species. We need to continue fieldwork to identify more fossils and determine how the species are related and how they lived. Ultimately, everything is connected."

The study, "Middle Miocene Pierolapithecus provides a first glimpse into early hominid pelvic morphology," will be published in an upcoming issue of the Journal of Human Evolution. The Department of Pathology and Anatomical Sciences is in the MU School of Medicine. Co-authors included David Alba from the Autonomous University of Barcelona in Spain and the University of Turin in Italy, Sergio Alm?cija from Stony Brook University in New York, and Salvador Moy?-Sol? from the Miquel Crusafont Institute of Catalan Palaeontology at Autonomous University of Barcelona.

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Journal Reference:

  1. Ashley S. Hammond, David M. Alba, Sergio Alm?cija, Salvador Moy?-Sol?. Middle Miocene Pierolapithecus provides a first glimpse into early hominid pelvic morphology. Journal of Human Evolution, 2013; DOI: 10.1016/j.jhevol.2013.03.002

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/Envk-jxfwjs/130501132100.htm

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Gigabit internet finds a new home in Omaha, Nebraska

Gigabit internet finds a new home in Omaha, Nebraska

When it comes to gigabit internet, the headline buzz usually involves Google and some mid or south western American locale. But not today. No, today, the ridiculously high-speed internet spotlight falls on Omaha, Nebraska where local provider CenturyLink is poised to launch a pilot service. Starting Monday, the telco's Lightspeed Broadband package ($150 a month for standalone service or $80 a month as a bundle) will go live for nearly 10,000 subscribers and continue to rollout to a footprint just shy of 50,000 residential and enterprise subs by October. Further expansion plans for the greater metro area all hinge upon whether CenturyLink can turn a profit on the service, but the company will continue to sign-up enterprise subs outside of this pilot zone for the next two years. The path forward -- at least, to us -- is pretty clear, Omahans: vote with your wallet if you want to preserve the gigabit bragging rights.

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